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The most scientifically advanced formulas designed to restore yourNAD+levels and optimize your potential for healthy longevity.

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You can't live without NAD+.

The bad news: NAD+ levels are destroyed by aging, inflammation, diet, stress, and sickness. This leads to weakness, frailty, and even faster aging.

The good news: You can help restore your NAD+ levels with exercise, nutrition, and targeted supplement formulas.

Optimize all 4 NAD+

biosynthesis pathways.

Science-backed protocols tailored to how your body actually works.

  • Why All 4 Pathways Matter

  • Build your Personalized Protocol

  • The Science of Aging

    Is it just aging, or are your NAD+ pathways slowing down?

    When one pathway stalls, your energy suffers.

    NAD+ is essential for energy, repair, and resilience. As we age, NAD+ synthesis pathways slow down, leading to a dramatic drop in cellular energy. By age 50, we have half of what we did when we were younger. Factors like poor diet, sedentary lifestyles, illness, and environmental toxins deplete NAD+ even faster.

    Our scientifically designed multi-pathway formulas restore NAD+ where your biology needs it most.

    NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. If you ran out, your body would stop working – within seconds. It fuels the enzymes responsible for DNA repair, energy production, cellular stress response, and gene expression. Without it, your cells can’t function, adapt, or repair themselves.

    As you age, your NAD+ levels drop up to 50% by age 50, and even more in tissues under metabolic stress. This decline isn’t just a side effect of aging: it’s a driver of it.

    The cellular energy crisis.

    Why Modern Life Destroys NAD+:

    • Blue light exposure disrupts circadian .NAD+.
    • Processed foods are inflammatory and increase CD38.
    • Chronic stress means constant repair demand.
    • Sedentary lifestyle damages mitochondrial function.
    • Poor sleep shortens or eliminates nightly recovery window.
    • Alcohol detoxification depletes NAD+ stores.

    The mismatch: Your body expects feast/famine cycles, sunrise/sunset rhythms, and physical demands. Instead, it gets constant food, artificial light, and Netflix.

    The solution: Since we can't live like our ancestors, we need to supplement what modern life depletes.

    The functional cost of NAD+ loss.

    YOU MAY NOT SEENAD+LEVELS DECLINE, BUT YOU CAN FEEL THE CONSEQUENCES.

    • Fatigue and poor recovery

      NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.

      NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.

    • Brain fog and forgetfulness

      NAD+ powers neuron firing and synaptic connections. Low NAD+ means slower thinking, poor focus, and that frustrating word-on-the-tip-of-your-tongue feeling.

      NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.

    • Weaker immunity

      NAD+ powers immune cell activation and inflammatory balance. Low NAD+ means longer recovery from illness and increased susceptibility to infections.

      NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.

    • Slower repair and regeneration

      NAD+ powers DNA repair and cellular regeneration. Low NAD+ means injuries heal slowly, skin ages faster, and recovery takes longer.

      NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.

      • Evidence for the four-pathway approach.

        We analyzed hundreds studies and found:

        → Multiple precursors work better:Different cells prefer different NAD+ builders.

        → CD38 is the hidden problem: It increases with age, eating your NAD+.

        → Mitochondria need support: Better efficiency = less NAD+ waste.

        → Sleep is when repair happens: Poor sleep = higher NAD+ demand.

      • Key Studies:

        • NMN improves insulin sensitivity (Science, 2021)
        • Quercetin inhibits CD38 (Diabetes, 2013)
        • Resveratrol enhances mitochondria (Cell Metabolism, 2011)
        • Spermidine activates autophagy (Nature Medicine, 2016)

        Taking NMN or NR alone is like filling a bucket with holes in it. Sure, you're adding NAD+ to your system by taking a precursor, but you're not addressing the enzymes like CD38 literally eating your NAD+ faster than you can make it, the inflammation driving those enzymes higher, the inefficient mitochondria wasting what NAD+ you do have, or the cellular damage creating constant NAD+ demand.

        NAD+ precursor response is personal.

        The enzymes that rebuild your NAD+ stores vary by person and tissue, so the same supplement doesn’t always produce the same effect.

        Supporting multiple pathways with NMN, NR, and Trigonelline helps you get reliable, steady NAD+ support without guesswork.

        NAD+ boosters like NMN and NR are only the beginning.

        After years of analyzing the research, we've aligned with a systems-level approach to address four main pathways to support healthy NAD+ levels throughout the entire body. This systems-level approach is described elegantly by Nichola Conlon and Dianne Ford in a recent study on NAD+ restoration.

        Every Renue By Science formula helps you maximize NAD+ through one of these pathways.

        • Boost
        • Protect
        • Optimize
        • Regenerate

        Liposomal delivery means greater bioavailability.

        Liposomal delivery wraps sensitive ingredients like NMN and NR in phospholipids, the same fats that make up cell membranes, so they’re protected during digestion and first-pass liver processing.

        This translates to more of the active ingredients reaching your cells where you need them most, and more powerful effects at significantly lower doses.